Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease.


Journal Article

The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity. We investigated the expression of the trk receptors in the parietal cortex (PC) and cerebellum of patients with Alzheimer's disease (AD) and age-matched controls. Cortical layers II-VI displayed a distinct cellular immunoreactivity for trk A and C with an emphasis in the pyramidal neurons of layers III and V. Trk B immunoreactivity was primarily located in the deeper cortical layers with a predominance in layer V. There was a decrease in trk A and C immunoreactivity in the PC of AD cases, while trk B density appeared to be unchanged. In addition, cerebellar Purkinje cells revealed a distinct immunoreactivity for trk C both in control and AD cases, suggesting trk C may be important in the maintenance of these cells in the aged brain.

Full Text

Cited Authors

  • Savaskan, E; Müller-Spahn, F; Olivieri, G; Bruttel, S; Otten, U; Rosenberg, C; Hulette, C; Hock, C

Published Date

  • 2000

Published In

Volume / Issue

  • 44 / 3

Start / End Page

  • 172 - 180

PubMed ID

  • 11053967

Pubmed Central ID

  • 11053967

International Standard Serial Number (ISSN)

  • 0014-3022

Digital Object Identifier (DOI)

  • 10.1159/000008229


  • eng

Conference Location

  • Switzerland