Ocular toxicity following high dose chemotherapy and autologous transplant.
Publication
, Journal Article
Rubin, P; Hulette, C; Khawly, JA; Elkordy, M; Hussein, A; Vredenburgh, JJ; Jaffe, GJ; Peters, WP
Published in: Bone Marrow Transplant
July 1996
A 49-year-old woman received an autologous transplant for breast cancer. Six weeks later she noticed visual disturbance of the left eye which correlated with a visual field abnormality. There was a milder degree of visual disturbance in the right eye. Treatment with high-dose steroids partially stabilized the problem, which was felt to be an ischemic optic neuropathy. She ultimately died of respiratory failure. Pathology of the optic nerves revealed demyelination. Visual disturbances following high-dose chemotherapy are uncommon; the pathology to date has not been elucidated. Steroid therapy may be useful.
Duke Scholars
Published In
Bone Marrow Transplant
ISSN
0268-3369
Publication Date
July 1996
Volume
18
Issue
1
Start / End Page
253 / 256
Location
England
Related Subject Headings
- Visual Fields
- Transplantation Conditioning
- Scotoma
- Respiratory Insufficiency
- Paraneoplastic Syndromes
- Optic Nerve
- Middle Aged
- Methotrexate
- Mastectomy, Modified Radical
- Ischemia
Citation
APA
Chicago
ICMJE
MLA
NLM
Rubin, P., Hulette, C., Khawly, J. A., Elkordy, M., Hussein, A., Vredenburgh, J. J., … Peters, W. P. (1996). Ocular toxicity following high dose chemotherapy and autologous transplant. Bone Marrow Transplant, 18(1), 253–256.
Rubin, P., C. Hulette, J. A. Khawly, M. Elkordy, A. Hussein, J. J. Vredenburgh, G. J. Jaffe, and W. P. Peters. “Ocular toxicity following high dose chemotherapy and autologous transplant.” Bone Marrow Transplant 18, no. 1 (July 1996): 253–56.
Rubin P, Hulette C, Khawly JA, Elkordy M, Hussein A, Vredenburgh JJ, et al. Ocular toxicity following high dose chemotherapy and autologous transplant. Bone Marrow Transplant. 1996 Jul;18(1):253–6.
Rubin, P., et al. “Ocular toxicity following high dose chemotherapy and autologous transplant.” Bone Marrow Transplant, vol. 18, no. 1, July 1996, pp. 253–56.
Rubin P, Hulette C, Khawly JA, Elkordy M, Hussein A, Vredenburgh JJ, Jaffe GJ, Peters WP. Ocular toxicity following high dose chemotherapy and autologous transplant. Bone Marrow Transplant. 1996 Jul;18(1):253–256.
Published In
Bone Marrow Transplant
ISSN
0268-3369
Publication Date
July 1996
Volume
18
Issue
1
Start / End Page
253 / 256
Location
England
Related Subject Headings
- Visual Fields
- Transplantation Conditioning
- Scotoma
- Respiratory Insufficiency
- Paraneoplastic Syndromes
- Optic Nerve
- Middle Aged
- Methotrexate
- Mastectomy, Modified Radical
- Ischemia