A neural survival factor is a candidate oncogene in breast cancer.

Published

Journal Article

Using serial analysis of gene expression (SAGE), we identified a SAGE tag that was present only in invasive breast carcinomas and their lymph node metastases. The transcript corresponding to this SAGE tag, dermcidin (DCD), encodes a secreted protein normally expressed only in the pons of the brain and sweat glands. Array comparative genomic hybridization, fluorescence in situ hybridization, and immunohistochemical analyses determined that DCD is overexpressed in approximately 10% of invasive breast carcinomas; in some cases its overexpression is coupled with a focal copy number gain of its locus at 12q13.1, and its expression is associated with advanced clinical stage and poor prognosis. Expression of DCD in breast cancer cells promotes cell growth and survival and reduces serum dependency. Putative high- and low-affinity receptors for DCD are present on the cell surface of breast carcinomas and neurons of the brain. Based on these data we hypothesize that DCD may play a role in tumorigenesis by means of enhancing cell growth and survival in a subset of breast carcinomas.

Full Text

Duke Authors

Cited Authors

  • Porter, D; Weremowicz, S; Chin, K; Seth, P; Keshaviah, A; Lahti-Domenici, J; Bae, YK; Monitto, CL; Merlos-Suarez, A; Chan, J; Hulette, CM; Richardson, A; Morton, CC; Marks, J; Duyao, M; Hruban, R; Gabrielson, E; Gelman, R; Polyak, K

Published Date

  • September 16, 2003

Published In

Volume / Issue

  • 100 / 19

Start / End Page

  • 10931 - 10936

PubMed ID

  • 12953101

Pubmed Central ID

  • 12953101

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.1932980100

Language

  • eng

Conference Location

  • United States