Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain.

Published

Journal Article

Involvement of the interleukin-6 receptor complex (IL-6RC) in neuroregulatory and immunological processes of the brain and particularly in Alzheimer's disease (AD) has been hypothesized. The functionally active IL-6RC consists of the cytokine IL-6, which acts through the ligand binding IL-6R and the signal transducing gp130. Using a new immunocytochemical protocol on rapid autopsy cryostat brain sections we studied the expression of the IL-6RC in Braak IV-V staged AD patients compared to normal age-matched controls (HC) across five different cortical regions. Inter-rater reliability of the method was high. The "baseline" expression in normal human brain was determined for IL-6,IL-6R and gp130 in all cortical regions. In normal tissue IL-6 expression was lower in parietal cortex. Higher IL-6R expression was shown in frontal, occipital and parietal cortex, lower expression in temporal cortex and cerebellum. In AD IL-6 expression levels were generally increased in parietal cortex and decreased in occipital cortex compared to controls. IL-6R expression levels were strongly increased in AD frontal and occipital cortex and decreased in temporal cortex and cerebellum. Our findings indicate an altered cortical immunoreactivity pattern of the functional IL-6RC in AD supporting the hypothesis of a disease-related role of IL-6 in AD pathophysiology.

Full Text

Cited Authors

  • Hampel, H; Haslinger, A; Scheloske, M; Padberg, F; Fischer, P; Unger, J; Teipel, SJ; Neumann, M; Rosenberg, C; Oshida, R; Hulette, C; Pongratz, D; Ewers, M; Kretzschmar, HA; Möller, H-J

Published Date

  • August 2005

Published In

Volume / Issue

  • 255 / 4

Start / End Page

  • 269 - 278

PubMed ID

  • 15565298

Pubmed Central ID

  • 15565298

International Standard Serial Number (ISSN)

  • 0940-1334

Digital Object Identifier (DOI)

  • 10.1007/s00406-004-0558-2

Language

  • eng

Conference Location

  • Germany