Pharmacological modulation of the contractile response to toluene diisocyanate in the rat isolated urinary bladder.

Published

Journal Article

1. Toluene diisocyanate produced concentration-dependent contractions of the rat isolated urinary bladder. 2. The contractions were tetrodotoxin-resistant and were abolished by previous exposure of the strips to capsaicin. 3. Indomethacin (5 microM) and ruthenium red (30 microM) inhibited toluene diisocyanate-induced contractions. Responses expressed as a percentage of the response obtained with substance P, 30 nM, were respectively 141.6 +/- 24.8% and 20.1 +/- 5.1% in control and indomethacin-treated strips (P less than 0.005); 123.0 +/- 30.2% and 14.0 +/- 6.5% in control and ruthenium red-treated strips (0.01 less than P less than 0.05). 4. These results suggest that toluene diisocyanate-induced contractions of the rat isolated bladder are the result of the release of cyclo-oxygenase products which may act by activating the capsaicin receptor.

Full Text

Cited Authors

  • Mapp, CE; Chitano, P; Fabbri, LM; Patacchini, R; Maggi, CA

Published Date

  • August 1990

Published In

Volume / Issue

  • 100 / 4

Start / End Page

  • 886 - 888

PubMed ID

  • 1698499

Pubmed Central ID

  • 1698499

Electronic International Standard Serial Number (EISSN)

  • 1476-5381

International Standard Serial Number (ISSN)

  • 0007-1188

Digital Object Identifier (DOI)

  • 10.1111/j.1476-5381.1990.tb14109.x

Language

  • eng