Mechanisms and pathology of occupational asthma.


Journal Article (Review)

Since the pathogenesis and the pathological features of occupational asthma are similar to those of nonoccupational asthma, the former represents a very useful model for the investigation of the pathogenesis of asthma in general. More than one mechanism may be operative in occupational asthma. Among the mechanisms proposed, immunological mechanisms and airway inflammation play an important role. There is evidence to confirm that T-lymphocyte activation and local accumulation in the bronchial wall of activated eosinophils occurs in asthma of diverse aetiology, i.e. immunoglobulin E (IgE)-mediated, occupational and intrinsic. Neurogenic pathways should be further investigated as a potential mechanism of modulation and amplification of airway inflammation in occupational asthma.

Full Text

Cited Authors

  • Mapp, CE; Saetta, M; Maestrelli, P; Di Stefano, A; Chitano, P; Boschetto, P; Ciaccia, A; Fabbri, LM

Published Date

  • March 1994

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 544 - 554

PubMed ID

  • 8013612

Pubmed Central ID

  • 8013612

Electronic International Standard Serial Number (EISSN)

  • 1399-3003

International Standard Serial Number (ISSN)

  • 0903-1936

Digital Object Identifier (DOI)

  • 10.1183/09031936.94.07030544


  • eng