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The effect of chronic caffeine administration on serum markers of bone mineral metabolism and bone histomorphometry in the rat.

Publication ,  Journal Article
Glajchen, N; Ismail, F; Epstein, S; Jowell, PS; Fallon, M
Published in: Calcif Tissue Int
November 1988

Caffeine has been cited as a risk factor for osteoporosis in humans. In rats, caffeine increases calcium absorption and excretion and raises parathyroid hormone (iPTH) levels. This study investigated the effect of chronic caffeine administration on bone histomorphometry and serum markers of bone mineral metabolism. Twenty-seven male Sprague Dawley rats weighing approximately 300 g were divided into three groups: Group A (n = 8) served as controls, Group B (n = 9) received 2.5 mg/100 g caffeine in their drinking water, and Group C (n = 10) received 10 mg/100 g body weight caffeine in their drinking water. Animals were bled serially for the 8 week study period: Ionized calcium was measured from tail vein blood and serum iPTH and osteocalcin (BGP) from orbital sinus blood. All three groups received two doses of tetracycline for bone histomorphometry which was performed on a right tibial section from each animal. Ionized calcium was not different among the three groups at any time point. No alteration in serum iPTH levels was demonstrated except for day 56 when the high-dose group (C) showed a raised level (mean = 59.1, SE = +/- 8.9 pg/ml (P less than 0.05). By week 8 Group C showed a failure to gain weight compared with Group A. Group C mean weight = 384.0 +/- 6.6 g, Group A 427.4 +/- 10.8 g (P less than 0.005). Serum BGP was significantly increased in Group C compared with control (P less than 0.001). No differences in bone histomorphometry were observed among the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)

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Published In

Calcif Tissue Int

DOI

ISSN

0171-967X

Publication Date

November 1988

Volume

43

Issue

5

Start / End Page

277 / 280

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Parathyroid Hormone
  • Osteocalcin
  • Minerals
  • Male
  • Endocrinology & Metabolism
  • Dose-Response Relationship, Drug
  • Calcium-Binding Proteins
  • Calcium
 

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Glajchen, N., Ismail, F., Epstein, S., Jowell, P. S., & Fallon, M. (1988). The effect of chronic caffeine administration on serum markers of bone mineral metabolism and bone histomorphometry in the rat. Calcif Tissue Int, 43(5), 277–280. https://doi.org/10.1007/BF02556635
Glajchen, N., F. Ismail, S. Epstein, P. S. Jowell, and M. Fallon. “The effect of chronic caffeine administration on serum markers of bone mineral metabolism and bone histomorphometry in the rat.Calcif Tissue Int 43, no. 5 (November 1988): 277–80. https://doi.org/10.1007/BF02556635.
Glajchen N, Ismail F, Epstein S, Jowell PS, Fallon M. The effect of chronic caffeine administration on serum markers of bone mineral metabolism and bone histomorphometry in the rat. Calcif Tissue Int. 1988 Nov;43(5):277–80.
Glajchen, N., et al. “The effect of chronic caffeine administration on serum markers of bone mineral metabolism and bone histomorphometry in the rat.Calcif Tissue Int, vol. 43, no. 5, Nov. 1988, pp. 277–80. Pubmed, doi:10.1007/BF02556635.
Glajchen N, Ismail F, Epstein S, Jowell PS, Fallon M. The effect of chronic caffeine administration on serum markers of bone mineral metabolism and bone histomorphometry in the rat. Calcif Tissue Int. 1988 Nov;43(5):277–280.
Journal cover image

Published In

Calcif Tissue Int

DOI

ISSN

0171-967X

Publication Date

November 1988

Volume

43

Issue

5

Start / End Page

277 / 280

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Parathyroid Hormone
  • Osteocalcin
  • Minerals
  • Male
  • Endocrinology & Metabolism
  • Dose-Response Relationship, Drug
  • Calcium-Binding Proteins
  • Calcium