Puzzling thoughts for H. M.: can new semantic information be anchored to old semantic memories?

Published

Journal Article

Researchers currently debate whether new semantic knowledge can be learned and retrieved despite extensive damage to medial temporal lobe (MTL) structures. The authors explored whether H. M., a patient with amnesia, could acquire new semantic information in the context of his lifelong hobby of solving crossword puzzles. First, H. M. was tested on a series of word-skills tests believed important in solving crosswords. He also completed 3 new crosswords: 1 puzzle testing pre-1953 knowledge, another testing post-1953 knowledge, and another combining the 2 by giving postoperative semantic clues for preoperative answers. From the results, the authors concluded that H. M. can acquire new semantic knowledge, at least temporarily, when he can anchor it to mental representations established preoperatively.

Full Text

Duke Authors

Cited Authors

  • Skotko, BG; Kensinger, EA; Locascio, JJ; Einstein, G; Rubin, DC; Tupler, LA; Krendl, A; Corkin, S

Published Date

  • October 2004

Published In

Volume / Issue

  • 18 / 4

Start / End Page

  • 756 - 769

PubMed ID

  • 15506844

Pubmed Central ID

  • 15506844

Electronic International Standard Serial Number (EISSN)

  • 1931-1559

International Standard Serial Number (ISSN)

  • 0894-4105

Digital Object Identifier (DOI)

  • 10.1037/0894-4105.18.4.756

Language

  • eng