Effect of alpha-isopropylmalate on the synthesis of RNA and protein in Neurospora.

Journal Article

The leu-3/alpha-IPM (alpha-isopropylmalate) regulatory system, previously shown to control several genes of leucine, isoleucine, valine, and histidine biosynthesis, appears likely to be involved also in the regulation of overall RNA and protein synthesis in Neurospora. Upon addition of alpha-IPM the synthesis of all major species of stable RNA was found to be transiently inhibited by approximately 50%. A similar reduction was observed in overall protein synthesis. The inhibition was dependent in both cases on a functional leu-3 gene product, in conformance with previously established patterns of alpha-IPM dependent gene regulation. The overt resemblance of the phenomenon described here to the 'stringent response' of bacteria is noted but neither the mechanism of inhibition nor the precise role of alpha-IPM in the process has been established.

Full Text

Duke Authors

Cited Authors

  • Armaleo, D; Fischer, M; Gross, SR

Published Date

  • January 1, 1985

Published In

Volume / Issue

  • 200 / 2

Start / End Page

  • 346 - 349

PubMed ID

  • 3162080

Pubmed Central ID

  • 3162080

International Standard Serial Number (ISSN)

  • 0026-8925

Digital Object Identifier (DOI)

  • 10.1007/bf00425447


  • eng