Structure and evolution of prokaryotic and eukaryotic RNA polymerases: a model.

Journal Article (Journal Article)

A comparative overview of the subunit taxonomy and sequences of eukaryotic and prokaryotic RNA polymerases indicates the presence of a core structure conserved between both sets of enzymes. The differentiation between prokaryotic and eukaryotic polymerases is ascribed to domains and subunits peripheral to the largely conserved central structure. Possible subunit and domain functions are outlined. The core's flexible shape is largely determined by the elongated architecture of the two largest subunits, which can be oriented along the DNA axis with their bulkier amino-terminal head regions looking towards the 3' end of the gene to be transcribed and their more slender carboxyl-terminal domains at the tail end of the enzyme. The two largest prokaryotic subunits appear originally derived from a single gene.

Full Text

Duke Authors

Cited Authors

  • Armaleo, D

Published Date

  • August 1987

Published In

Volume / Issue

  • 127 / 3

Start / End Page

  • 301 - 314

PubMed ID

  • 3431127

Electronic International Standard Serial Number (EISSN)

  • 1095-8541

International Standard Serial Number (ISSN)

  • 0022-5193

Digital Object Identifier (DOI)

  • 10.1016/s0022-5193(87)80108-x


  • eng