Platinum-catalyzed intermolecular hydroamination of vinyl arenes with carboxamides.
Published
Journal Article
[reaction: see text] Reaction of benzamide with 4-methylstyrene catalyzed by a 1:2 mixture of [PtCl(2)(H(2)C=CH(2))](2) and P(4-C(6)H(4)CF(3))(3) (5 mol %) in mesitylene at 140 degrees C for 24 h led to the isolation of N-(1-p-tolylethyl)benzamide in 85% yield. Electron-rich, electron-poor, and hindered vinyl arenes underwent Markovnikov hydroamination with a range of carboxamides and amide derivatives in moderate to good yield with excellent regioselectivity.
Full Text
Duke Authors
Cited Authors
- Qian, H; Widenhoefer, RA
Published Date
- June 2005
Published In
Volume / Issue
- 7 / 13
Start / End Page
- 2635 - 2638
PubMed ID
- 15957909
Pubmed Central ID
- 15957909
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7060
Digital Object Identifier (DOI)
- 10.1021/ol050745f
Language
- eng