Platinum-catalyzed intermolecular hydroamination of vinyl arenes with carboxamides.

Journal Article (Journal Article)

[reaction: see text] Reaction of benzamide with 4-methylstyrene catalyzed by a 1:2 mixture of [PtCl(2)(H(2)C=CH(2))](2) and P(4-C(6)H(4)CF(3))(3) (5 mol %) in mesitylene at 140 degrees C for 24 h led to the isolation of N-(1-p-tolylethyl)benzamide in 85% yield. Electron-rich, electron-poor, and hindered vinyl arenes underwent Markovnikov hydroamination with a range of carboxamides and amide derivatives in moderate to good yield with excellent regioselectivity.

Full Text

Duke Authors

Cited Authors

  • Qian, H; Widenhoefer, RA

Published Date

  • June 2005

Published In

Volume / Issue

  • 7 / 13

Start / End Page

  • 2635 - 2638

PubMed ID

  • 15957909

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol050745f


  • eng