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Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines.

Publication ,  Journal Article
Bender, CF; Widenhoefer, RA
Published in: Journal of the American Chemical Society
February 2005

Reaction of benzyl-2,2-diphenyl-4-pentenylamine with a catalytic 1:2 mixture of [PtCl2(H2C=CH2)]2 (2.5 mol %) and PPh3 in dioxane at 120 degrees C for 16 h led to isolation of 1-benzyl-2-methyl-4,4-diphenylpyrrolidine in 75% yield. A number of gamma- and delta-amino olefins underwent intramolecular hydroamination to form the corresponding pyrrolidine derivatives in moderate to good yield. The reaction displayed excellent functional group compatibility and low moisture sensitivity.

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Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

February 2005

Volume

127

Issue

4

Start / End Page

1070 / 1071

Related Subject Headings

  • Organoplatinum Compounds
  • General Chemistry
  • Catalysis
  • Amines
  • Amination
  • Alkenes
  • 40 Engineering
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

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Bender, C. F., & Widenhoefer, R. A. (2005). Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines. Journal of the American Chemical Society, 127(4), 1070–1071. https://doi.org/10.1021/ja043278q
Bender, Christopher F., and Ross A. Widenhoefer. “Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines.Journal of the American Chemical Society 127, no. 4 (February 2005): 1070–71. https://doi.org/10.1021/ja043278q.
Bender CF, Widenhoefer RA. Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines. Journal of the American Chemical Society. 2005 Feb;127(4):1070–1.
Bender, Christopher F., and Ross A. Widenhoefer. “Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines.Journal of the American Chemical Society, vol. 127, no. 4, Feb. 2005, pp. 1070–71. Epmc, doi:10.1021/ja043278q.
Bender CF, Widenhoefer RA. Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines. Journal of the American Chemical Society. 2005 Feb;127(4):1070–1071.
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

February 2005

Volume

127

Issue

4

Start / End Page

1070 / 1071

Related Subject Headings

  • Organoplatinum Compounds
  • General Chemistry
  • Catalysis
  • Amines
  • Amination
  • Alkenes
  • 40 Engineering
  • 34 Chemical sciences
  • 03 Chemical Sciences