Statistical inference of sequence-dependent mutation rates.

Published

Journal Article (Review)

Several lines of research are now converging towards an integrated understanding of mutational mechanisms and their evolutionary implications. Experimentally, crystal structures reveal the effect of sequence context on polymerase fidelity; large-scale sequencing projects generate vast amounts of sequence polymorphism data; and locus-specific databases are being constructed. Computationally, software and analytical tools have been developed to analyze mutational data, to identify mutational hot spots, and to compare the signatures of mutagenic agents.

Full Text

Cited Authors

  • Zavolan, M; Kepler, TB

Published Date

  • December 2001

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 612 - 615

PubMed ID

  • 11682302

Pubmed Central ID

  • 11682302

International Standard Serial Number (ISSN)

  • 0959-437X

Language

  • eng

Conference Location

  • England