Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation.


Journal Article (Review)

Affinity maturation of the humoral immune response by somatic hypermutation is marked by a rapid and dramatic increase in affinity for the eliciting antigen. We suggest that the optimal mutation schedule is one in which periods of rapid mutation alternate with periods of mutation-free growth. The multicompartmental structure of the germinal center, together with re-entry of positively selected B cells back into the germinal center, will naturally implement such a schedule, thereby providing an anatomical basis for the efficiency of the germinal center reaction.

Full Text

Cited Authors

  • Kepler, TB; Perelson, AS

Published Date

  • August 1993

Published In

Volume / Issue

  • 14 / 8

Start / End Page

  • 412 - 415

PubMed ID

  • 8397781

Pubmed Central ID

  • 8397781

International Standard Serial Number (ISSN)

  • 0167-5699

Digital Object Identifier (DOI)

  • 10.1016/0167-5699(93)90145-B


  • eng

Conference Location

  • England