Diversification of Ig superfamily genes in an invertebrate.


Journal Article

The freshwater snail Biomphalaria glabrata possesses a diverse family of fibrinogen-related proteins (FREPs), hemolymph polypeptides that consist of one or two amino-terminal immunoglobulin superfamily (IgSF) domains and a carboxyl-terminal fibrinogen domain. Here, we show that the IgSF1 domain of the FREP3 subfamily is diversified at the genomic level at higher rates than those recorded for control genes. All sequence variants are derived from a small set of nine source sequences by point mutation and recombinatorial processes. Diverse FREP3 transcripts are also produced. We hypothesize a mechanism present in snails that is capable of diversifying molecules involved in internal defense.

Full Text

Cited Authors

  • Zhang, S-M; Adema, CM; Kepler, TB; Loker, ES

Published Date

  • July 9, 2004

Published In

Volume / Issue

  • 305 / 5681

Start / End Page

  • 251 - 254

PubMed ID

  • 15247481

Pubmed Central ID

  • 15247481

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1088069


  • eng

Conference Location

  • United States