Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms.
Journal Article
A review of the literature reveals that glucocorticoids have: 1) a protective effect both in vitro and in vivo against bacterial endotoxins and exotoxins, and 2) a protective or therapeutic effect in sepsis/shock caused by Gram-negative microorganisms. At the Columbia Presbyterian Medical Center, the 1968-1973 mortality rate for general sepsis/shock due to Gram-negative organisms was 16.6 percent and for urologic sepsis/shock 15.3 percent. This low rate was the result of early diagnosis and early use of massive dosages of glucocorticoids (hydrocortisone, methylprednisolone, dexamethasone), beta-adrenergic isoproterenol, and bactericidal antibiotics (gentamicin, kanamycin, carbenicillin, cephalothin-cefazolin, ampicillin).
Full Text
Duke Authors
Cited Authors
- Seneca, H; Grant, JP
Published Date
- November 1, 1975
Published In
Volume / Issue
- 23 / 11
Start / End Page
- 493 - 502
PubMed ID
- 1176749
Pubmed Central ID
- 1176749
International Standard Serial Number (ISSN)
- 0002-8614
Digital Object Identifier (DOI)
- 10.1111/j.1532-5415.1975.tb00895.x
Language
- eng
Conference Location
- United States