Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms.

Journal Article (Journal Article)

A review of the literature reveals that glucocorticoids have: 1) a protective effect both in vitro and in vivo against bacterial endotoxins and exotoxins, and 2) a protective or therapeutic effect in sepsis/shock caused by Gram-negative microorganisms. At the Columbia Presbyterian Medical Center, the 1968-1973 mortality rate for general sepsis/shock due to Gram-negative organisms was 16.6 percent and for urologic sepsis/shock 15.3 percent. This low rate was the result of early diagnosis and early use of massive dosages of glucocorticoids (hydrocortisone, methylprednisolone, dexamethasone), beta-adrenergic isoproterenol, and bactericidal antibiotics (gentamicin, kanamycin, carbenicillin, cephalothin-cefazolin, ampicillin).

Full Text

Duke Authors

Cited Authors

  • Seneca, H; Grant, JP

Published Date

  • November 1, 1975

Published In

Volume / Issue

  • 23 / 11

Start / End Page

  • 493 - 502

PubMed ID

  • 1176749

International Standard Serial Number (ISSN)

  • 0002-8614

Digital Object Identifier (DOI)

  • 10.1111/j.1532-5415.1975.tb00895.x


  • eng

Conference Location

  • United States