Nitrogen-sparing intravenous fluids in postperative patients.

Journal Article (Clinical Trial;Journal Article)

Improved nitrogen sparing was demonstrated in 20 patients undergoing either head-and-neck operations or abdominal explorations, who were randomized to receive intravenously either 3 per cent amino acids or 5 per cent dextrose. Infusions were started immediately after operation and continued for a minimum of six days. In patients receiving amino acids, as compared with those receiving dextrose, mean cumulative six-day nitrogen losses were significantly lower (42 plus or minus 5 g [S.E.M.] and 74 plus or minus 7 g, respectively--P smaller 0.005), as were serum glucose and insulin levels, but beta-hydroxybutyrate, acetoacetate and blood urea nitrogen were significantly elevated. No adverse effects of the amino acid solution were observed. The presumed mechanism for improved nitrogen sparing is a decrease in serum glucose and insulin levels, allowing greater endogenous fat mobilization and utilization, thus sparing lean body mass.

Full Text

Duke Authors

Cited Authors

  • Hoover, HC; Grant, JP; Gorschboth, C; Ketcham, AS

Published Date

  • July 24, 1975

Published In

Volume / Issue

  • 293 / 4

Start / End Page

  • 172 - 175

PubMed ID

  • 806018

International Standard Serial Number (ISSN)

  • 0028-4793

Digital Object Identifier (DOI)

  • 10.1056/NEJM197507242930404


  • eng

Conference Location

  • United States