Nitrogen-sparing intravenous fluids in postperative patients.
Published
Journal Article
Improved nitrogen sparing was demonstrated in 20 patients undergoing either head-and-neck operations or abdominal explorations, who were randomized to receive intravenously either 3 per cent amino acids or 5 per cent dextrose. Infusions were started immediately after operation and continued for a minimum of six days. In patients receiving amino acids, as compared with those receiving dextrose, mean cumulative six-day nitrogen losses were significantly lower (42 plus or minus 5 g [S.E.M.] and 74 plus or minus 7 g, respectively--P smaller 0.005), as were serum glucose and insulin levels, but beta-hydroxybutyrate, acetoacetate and blood urea nitrogen were significantly elevated. No adverse effects of the amino acid solution were observed. The presumed mechanism for improved nitrogen sparing is a decrease in serum glucose and insulin levels, allowing greater endogenous fat mobilization and utilization, thus sparing lean body mass.
Full Text
Duke Authors
Cited Authors
- Hoover, HC; Grant, JP; Gorschboth, C; Ketcham, AS
Published Date
- July 24, 1975
Published In
Volume / Issue
- 293 / 4
Start / End Page
- 172 - 175
PubMed ID
- 806018
Pubmed Central ID
- 806018
International Standard Serial Number (ISSN)
- 0028-4793
Digital Object Identifier (DOI)
- 10.1056/NEJM197507242930404
Language
- eng
Conference Location
- United States