Skip to main content

Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana.

Publication ,  Journal Article
Haubold, B; Kroymann, J; Ratzka, A; Mitchell-Olds, T; Wiehe, T
Published in: Genetics
July 2002

Arabidopsis thaliana is a highly selfing plant that nevertheless appears to undergo substantial recombination. To reconcile its selfing habit with the observations of recombination, we have sampled the genetic diversity of A. thaliana at 14 loci of approximately 500 bp each, spread across 170 kb of genomic sequence centered on a QTL for resistance to herbivory. A total of 170 of the 6321 nucleotides surveyed were polymorphic, with 169 being biallelic. The mean silent genetic diversity (pi(s)) varied between 0.001 and 0.03. Pairwise linkage disequilibria between the polymorphisms were negatively correlated with distance, although this effect vanished when only pairs of polymorphisms with four haplotypes were included in the analysis. The absence of a consistent negative correlation between distance and linkage disequilibrium indicated that gene conversion might have played an important role in distributing genetic diversity throughout the region. We tested this by coalescent simulations and estimate that up to 90% of recombination is due to gene conversion.

Duke Scholars

Published In

Genetics

DOI

EISSN

1943-2631

ISSN

0016-6731

Publication Date

July 2002

Volume

161

Issue

3

Start / End Page

1269 / 1278

Related Subject Headings

  • Recombination, Genetic
  • Quantitative Trait Loci
  • Molecular Sequence Data
  • Models, Theoretical
  • Linkage Disequilibrium
  • Genome, Plant
  • Gene Conversion
  • Developmental Biology
  • DNA Primers
  • Base Sequence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Haubold, B., Kroymann, J., Ratzka, A., Mitchell-Olds, T., & Wiehe, T. (2002). Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana. Genetics, 161(3), 1269–1278. https://doi.org/10.1093/genetics/161.3.1269
Haubold, Bernhard, Jürgen Kroymann, Andreas Ratzka, Thomas Mitchell-Olds, and Thomas Wiehe. “Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana.Genetics 161, no. 3 (July 2002): 1269–78. https://doi.org/10.1093/genetics/161.3.1269.
Haubold B, Kroymann J, Ratzka A, Mitchell-Olds T, Wiehe T. Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana. Genetics. 2002 Jul;161(3):1269–78.
Haubold, Bernhard, et al. “Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana.Genetics, vol. 161, no. 3, July 2002, pp. 1269–78. Epmc, doi:10.1093/genetics/161.3.1269.
Haubold B, Kroymann J, Ratzka A, Mitchell-Olds T, Wiehe T. Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana. Genetics. 2002 Jul;161(3):1269–1278.

Published In

Genetics

DOI

EISSN

1943-2631

ISSN

0016-6731

Publication Date

July 2002

Volume

161

Issue

3

Start / End Page

1269 / 1278

Related Subject Headings

  • Recombination, Genetic
  • Quantitative Trait Loci
  • Molecular Sequence Data
  • Models, Theoretical
  • Linkage Disequilibrium
  • Genome, Plant
  • Gene Conversion
  • Developmental Biology
  • DNA Primers
  • Base Sequence