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Adverse events associated with hepatitis B vaccine in U.S. children less than six years of age, 1993 and 1994.

Publication ,  Journal Article
Fisher, MA; Eklund, SA; James, SA; Lin, X
Published in: Annals of epidemiology
January 2001

This study evaluated infrequent adverse reactions to hepatitis B vaccine by investigating the association of this vaccine with adverse health outcomes for U.S. children less than six years of age. The evaluation of the association between hepatitis B vaccine and chronic arthritis provides needed data, relevant to the Institute of Medicine's Report that there are inadequate data available to assess the causal relationship of hepatitis B vaccine to arthritis risk.The 1993 (n = 5505 children) and 1994 (n = 6515 children) National Health Interview Survey (NHIS) datasets were analyzed to provide post-marketing surveillance data from probability samples of the U.S. population. Incident cases of adverse events were determined from the temporal association between the hepatitis B vaccination and the adverse events. Logistic regression modeling was used to adjust for potential confounding.Controlling for age, race, and gender simultaneously in the 1994 NHIS, hepatitis B vaccine was found to be associated with prevalent arthritis [odds ratio (OR) = 5.91, 95% confidence interval (CI) = 1.05-33.14], incident acute ear infections (OR = 1.60, 95% CI = 1.00-2.58), and incident pharyngitis/nasopharyngitis (OR = 1.41, 95% CI = 0.95-2.09).Evidence from this study suggests that hepatitis B vaccine is positively associated with adverse health outcomes in the general population of US children.

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Published In

Annals of epidemiology

DOI

EISSN

1873-2585

ISSN

1047-2797

Publication Date

January 2001

Volume

11

Issue

1

Start / End Page

13 / 21

Related Subject Headings

  • United States
  • Retrospective Studies
  • Pharyngitis
  • Otitis
  • Male
  • Logistic Models
  • Infant
  • Humans
  • Hepatitis B Vaccines
  • Health Surveys
 

Citation

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ICMJE
MLA
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Fisher, M. A., Eklund, S. A., James, S. A., & Lin, X. (2001). Adverse events associated with hepatitis B vaccine in U.S. children less than six years of age, 1993 and 1994. Annals of Epidemiology, 11(1), 13–21. https://doi.org/10.1016/s1047-2797(00)00078-8
Fisher, M. A., S. A. Eklund, S. A. James, and X. Lin. “Adverse events associated with hepatitis B vaccine in U.S. children less than six years of age, 1993 and 1994.Annals of Epidemiology 11, no. 1 (January 2001): 13–21. https://doi.org/10.1016/s1047-2797(00)00078-8.
Fisher MA, Eklund SA, James SA, Lin X. Adverse events associated with hepatitis B vaccine in U.S. children less than six years of age, 1993 and 1994. Annals of epidemiology. 2001 Jan;11(1):13–21.
Fisher, M. A., et al. “Adverse events associated with hepatitis B vaccine in U.S. children less than six years of age, 1993 and 1994.Annals of Epidemiology, vol. 11, no. 1, Jan. 2001, pp. 13–21. Epmc, doi:10.1016/s1047-2797(00)00078-8.
Fisher MA, Eklund SA, James SA, Lin X. Adverse events associated with hepatitis B vaccine in U.S. children less than six years of age, 1993 and 1994. Annals of epidemiology. 2001 Jan;11(1):13–21.
Journal cover image

Published In

Annals of epidemiology

DOI

EISSN

1873-2585

ISSN

1047-2797

Publication Date

January 2001

Volume

11

Issue

1

Start / End Page

13 / 21

Related Subject Headings

  • United States
  • Retrospective Studies
  • Pharyngitis
  • Otitis
  • Male
  • Logistic Models
  • Infant
  • Humans
  • Hepatitis B Vaccines
  • Health Surveys