The quantity and quality of worldwide new drug introductions, 1982-2003.


Journal Article

We examined trends in the introduction of new chemical entities (NCEs) worldwide from 1982 through 2003. Although annual introductions of NCEs decreased over time, introductions of high-quality NCEs (that is, global and first-in-class NCEs) increased moderately. Both biotech and orphan products enjoyed tremendous growth, especially for cancer treatment. Country-level analyses for 1993-2003 indicate that U.S. firms overtook their European counterparts in innovative performance or the introduction of first-in-class, biotech, and orphan products. The United States also became the leading market for first launch.

Full Text

Duke Authors

Cited Authors

  • Grabowski, HG; Wang, YR

Published Date

  • March 2006

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 452 - 460

PubMed ID

  • 16522586

Pubmed Central ID

  • 16522586

Electronic International Standard Serial Number (EISSN)

  • 1544-5208

International Standard Serial Number (ISSN)

  • 0278-2715

Digital Object Identifier (DOI)

  • 10.1377/hlthaff.25.2.452


  • eng