The quantity and quality of worldwide new drug introductions, 1982-2003.

Journal Article (Journal Article)

We examined trends in the introduction of new chemical entities (NCEs) worldwide from 1982 through 2003. Although annual introductions of NCEs decreased over time, introductions of high-quality NCEs (that is, global and first-in-class NCEs) increased moderately. Both biotech and orphan products enjoyed tremendous growth, especially for cancer treatment. Country-level analyses for 1993-2003 indicate that U.S. firms overtook their European counterparts in innovative performance or the introduction of first-in-class, biotech, and orphan products. The United States also became the leading market for first launch.

Full Text

Duke Authors

Cited Authors

  • Grabowski, HG; Wang, YR

Published Date

  • March 2006

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 452 - 460

PubMed ID

  • 16522586

Electronic International Standard Serial Number (EISSN)

  • 1544-5208

International Standard Serial Number (ISSN)

  • 0278-2715

Digital Object Identifier (DOI)

  • 10.1377/hlthaff.25.2.452


  • eng