Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.
A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.
Frey, S; Dagan, R; Ashur, Y; Chen, XQ; Ibarra, J; Kollaritsch, H; Mazur, MH; Poland, GA; Reisinger, K; Walter, E; Van Damme, P; Braconier, JH; Uhnoo, I; Wahl, M; Blatter, MM; Clements, D; Greenberg, D; Jacobson, RM; Norrby, SR; Rowe, M; Shouval, D; Simmons, SS; van Hattum, J; Wennerholm, S; Gress, JO
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