CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition.

Published

Journal Article

We evaluated MHC-class I-restricted CTL responses induced by HIV-1 clade B-based vaccines in nine HIV-1 seronegative vaccine recipients with regard to their patterns of HLA restriction and epitope recognition. We found that seven of nine volunteers developed detectable CTL reactivities against novel epitopes within the HIV-1 Env and Gag proteins. Although four of nine subjects were HLA-A*0201, none of the cellular responses was restricted in the context of this allele. The type of responses observed in this sampling of vaccines appeared similar to those reported during primary infection and among long term non-progressors, with three out of nine subjects recognizing HLA-B27 or HLA-B17(57)-restricted epitopes. Although the majority of CTL responses were directed against novel epitopes, these effectors were still able to mediate cross-clade reactivities.

Full Text

Duke Authors

Cited Authors

  • Ferrari, G; Neal, W; Jones, A; Olender, N; Ottinger, J; Ha, R; McElrath, MJ; Goepfert, P; Weinhold, KJ

Published Date

  • November 1, 2001

Published In

Volume / Issue

  • 79 / 1-2

Start / End Page

  • 37 - 45

PubMed ID

  • 11595288

Pubmed Central ID

  • 11595288

International Standard Serial Number (ISSN)

  • 0165-2478

Language

  • eng

Conference Location

  • Netherlands