Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy.
Journal Article (Journal Article)
A dissociation between plasma human immunodeficiency virus (HIV) RNA levels and CD4(+) cell counts has been reported in patients experiencing viral relapse while receiving antiretroviral therapy. This study compared patients with stable CD4(+) lymphocytes during viral relapse while receiving treatment with patients who had sustained virus suppression. Plasma HIV RNA levels, lymphocyte immunophenotyping, and T cell receptor excision circle (TREC) levels were measured. Naive CD4(+) lymphocyte phenotype and TREC levels were not significantly different in patients with virus suppression or in those who had relapsed. However, CD8(+) lymphocyte activation, including the number and percentage of activated cells and CD38 antibody-binding capacity, was significantly elevated during viral relapse, compared with that in suppressed patients. By multivariable regression analyses, CD8(+) and CD4(+) lymphocyte activation were associated significantly with increasing plasma HIV RNA levels.
Full Text
Duke Authors
Cited Authors
- Wellons, MF; Ottinger, JS; Weinhold, KJ; Gryszowka, V; Sanders, LL; Edwards, LJ; Gooding, ME; Thomasch, JR; Bartlett, JA
Published Date
- May 15, 2001
Published In
Volume / Issue
- 183 / 10
Start / End Page
- 1522 - 1525
PubMed ID
- 11319689
Pubmed Central ID
- 11319689
International Standard Serial Number (ISSN)
- 0022-1899
Digital Object Identifier (DOI)
- 10.1086/320193
Language
- eng
Conference Location
- United States