Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy.

Journal Article (Journal Article)

A dissociation between plasma human immunodeficiency virus (HIV) RNA levels and CD4(+) cell counts has been reported in patients experiencing viral relapse while receiving antiretroviral therapy. This study compared patients with stable CD4(+) lymphocytes during viral relapse while receiving treatment with patients who had sustained virus suppression. Plasma HIV RNA levels, lymphocyte immunophenotyping, and T cell receptor excision circle (TREC) levels were measured. Naive CD4(+) lymphocyte phenotype and TREC levels were not significantly different in patients with virus suppression or in those who had relapsed. However, CD8(+) lymphocyte activation, including the number and percentage of activated cells and CD38 antibody-binding capacity, was significantly elevated during viral relapse, compared with that in suppressed patients. By multivariable regression analyses, CD8(+) and CD4(+) lymphocyte activation were associated significantly with increasing plasma HIV RNA levels.

Full Text

Duke Authors

Cited Authors

  • Wellons, MF; Ottinger, JS; Weinhold, KJ; Gryszowka, V; Sanders, LL; Edwards, LJ; Gooding, ME; Thomasch, JR; Bartlett, JA

Published Date

  • May 15, 2001

Published In

Volume / Issue

  • 183 / 10

Start / End Page

  • 1522 - 1525

PubMed ID

  • 11319689

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/320193


  • eng

Conference Location

  • United States