A dose-ranging study of a prototype synthetic HIV-1MN V3 branched peptide vaccine. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.

Published

Journal Article

A phase I double-blind trial was done to examine the safety and immunogenicity of a prototype synthetic human immunodeficiency virus type 1 MN strain (HIV-1MN) third variable region domain (V3) branched peptide vaccine in HIV-1-uninfected healthy adult volunteers. Subjects were randomly assigned to receive 20, 100, or 500 micrograms of vaccine or alum adjuvant control on days 0, 28, and 168. The vaccine was well-tolerated and appeared safe. Induction of binding antibody to V3 MN branched peptide was vaccine dose-related and was detectable in 9 of 10 subjects in the highest-vaccine-dose group. HIV-1MN-neutralizing antibody was detected after the third 500-micrograms dose in 8 of 10 subjects at the 90% neutralization end point. V3 MN peptide stimulated lymphocyte proliferation in 15 (75%) of 20 subjects after vaccination. In conclusion, this prototype vaccine was safe and it induced humoral and cell-mediated immune responses.

Full Text

Duke Authors

Cited Authors

  • Gorse, GJ; Keefer, MC; Belshe, RB; Matthews, TJ; Forrest, BD; Hsieh, RH; Koff, WC; Hanson, CV; Dolin, R; Weinhold, KJ; Frey, SE; Ketter, N; Fast, PE

Published Date

  • February 1996

Published In

Volume / Issue

  • 173 / 2

Start / End Page

  • 330 - 339

PubMed ID

  • 8568293

Pubmed Central ID

  • 8568293

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/173.2.330

Language

  • eng