The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene.

Journal Article (Journal Article)

We undertook linkage analysis in four large North Carolina kindreds with X-linked hypophosphatemic rickets (HYP) using a newly defined polymorphic probe, derived from the 5' untranslated portion of the human glycine receptor (GLR). Two-point linkage analysis established linkage between GLR and HYP [Z(theta) = 7.91 at theta = 0.07] and confirmed linkage between HYP and DXS41 [Z(theta) = 8.31 at theta = 0.06] and DXS43 [Z(theta) = 5.94 at theta = 0.05]. Additionally, we found GLR tightly linked to DXS43 [Z(theta) = 5.40 at theta = 0.0]. Multipoint analysis indicated that GLR is on the telomeric side of HYP with a map order of Xpcen-DXS41-HYP-(GLR/DSX43).

Full Text

Duke Authors

Cited Authors

  • Econs, MJ; Pericak-Vance, MA; Betz, H; Bartlett, RJ; Speer, MC; Drezner, MK

Published Date

  • July 1990

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 439 - 441

PubMed ID

  • 2163973

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(90)90180-3


  • eng

Conference Location

  • United States