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Genetic linkage studies in Alzheimer's disease families.

Publication ,  Journal Article
Pericak-Vance, MA; Yamaoka, LH; Haynes, CS; Speer, MC; Haines, JL; Gaskell, PC; Hung, WY; Clark, CM; Heyman, AL; Trofatter, JA
Published in: Exp Neurol
December 1988

Alzheimer's disease is a devastating neurological disorder and the leading cause of dementia among the elderly. Recent studies have localized the gene for familial Alzheimer's disease to chromosome 21 in a series of early onset AD families (mean age of onset less than 60). Familial late onset AD (mean age of onset greater than 60) is a more common clinical form of the disorder. Thirteen families with multiply affected Alzheimer's disease family members were identified and sampled. Ten of these families were of the late onset Alzheimer's disease type. Simulation studies were used to evaluate the usefulness of these pedigrees in linkage studies in familial Alzheimer's disease. Linkage studies undertaken to test the localization of both early onset and late onset Alzheimer's disease families to chromosome 21 failed to establish linkage and excluded linkage from a large portion of the region where the early onset Alzheimer's disease gene was localized. These findings suggest that more than one etiology may exist for familial Alzheimer's disease and indicate the need for continued screening of the genome in familial Alzheimer's disease families.

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Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

December 1988

Volume

102

Issue

3

Start / End Page

271 / 279

Location

United States

Related Subject Headings

  • Software
  • Pedigree
  • Neurology & Neurosurgery
  • Models, Genetic
  • Middle Aged
  • Humans
  • Genetic Linkage
  • Gene Frequency
  • Alzheimer Disease
  • 5202 Biological psychology
 

Citation

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Chicago
ICMJE
MLA
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Pericak-Vance, M. A., Yamaoka, L. H., Haynes, C. S., Speer, M. C., Haines, J. L., Gaskell, P. C., … Trofatter, J. A. (1988). Genetic linkage studies in Alzheimer's disease families. Exp Neurol, 102(3), 271–279. https://doi.org/10.1016/0014-4886(88)90220-8
Pericak-Vance, M. A., L. H. Yamaoka, C. S. Haynes, M. C. Speer, J. L. Haines, P. C. Gaskell, W. Y. Hung, C. M. Clark, A. L. Heyman, and J. A. Trofatter. “Genetic linkage studies in Alzheimer's disease families.Exp Neurol 102, no. 3 (December 1988): 271–79. https://doi.org/10.1016/0014-4886(88)90220-8.
Pericak-Vance MA, Yamaoka LH, Haynes CS, Speer MC, Haines JL, Gaskell PC, et al. Genetic linkage studies in Alzheimer's disease families. Exp Neurol. 1988 Dec;102(3):271–9.
Pericak-Vance, M. A., et al. “Genetic linkage studies in Alzheimer's disease families.Exp Neurol, vol. 102, no. 3, Dec. 1988, pp. 271–79. Pubmed, doi:10.1016/0014-4886(88)90220-8.
Pericak-Vance MA, Yamaoka LH, Haynes CS, Speer MC, Haines JL, Gaskell PC, Hung WY, Clark CM, Heyman AL, Trofatter JA. Genetic linkage studies in Alzheimer's disease families. Exp Neurol. 1988 Dec;102(3):271–279.
Journal cover image

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

December 1988

Volume

102

Issue

3

Start / End Page

271 / 279

Location

United States

Related Subject Headings

  • Software
  • Pedigree
  • Neurology & Neurosurgery
  • Models, Genetic
  • Middle Aged
  • Humans
  • Genetic Linkage
  • Gene Frequency
  • Alzheimer Disease
  • 5202 Biological psychology