Genetic susceptibility to Alzheimer disease.

Journal Article (Journal Article;Review)

Alzheimer disease (AD) is the leading cause of dementia in the elderly. Less than a decade ago, it was questioned as to whether or not genes were even involved in anything but rare early onset AD. Since that time, using a variety of genetic epidemiological and molecular biological techniques, four loci have been identified that play a role in the genetic susceptibility of AD. AD presents as a prototype of the power of genetic techniques in defining the etiology of a complex disease.

Full Text

Duke Authors

Cited Authors

  • Pericak-Vance, MA; Haines, JL

Published Date

  • December 1995

Published In

Volume / Issue

  • 11 / 12

Start / End Page

  • 504 - 508

PubMed ID

  • 8533168

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/s0168-9525(00)89161-1


  • eng

Conference Location

  • England