Genetic epidemiology of the susceptibility to leprosy.

Published

Journal Article

To test the hypothesis that genetic factors are operative in the predisposition to leprosy (Hansen's disease) in humans, a genetic epidemiologic investigation was performed on 269 leprosy kindreds containing 552 affected individuals from an isolated population in Papua New Guinea. The community, and not the family, was the basic social unit. Leprosy, an infectious disease, was not communal but strongly familial within the Karimui. Segregation analysis, to determine whether a major gene for the susceptibility to leprosy was segregating within a single multi-generational kindred, could not differentiate between a Mendelian genetic and a purely environmental hypothesis. The composite kindred data, however, suggest a genetic hypothesis for the non-immunologically induced susceptibility to leprosy per se. Within familial kindreds leprosy invariably emanated from a common ancestral sibship, and risk was associated with the closeness of kin but not with infectivity or severity.

Full Text

Duke Authors

Cited Authors

  • Shields, ED; Russell, DA; Pericak-Vance, MA

Published Date

  • April 1, 1987

Published In

Volume / Issue

  • 79 / 4

Start / End Page

  • 1139 - 1143

PubMed ID

  • 3549780

Pubmed Central ID

  • 3549780

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI112930

Language

  • eng

Conference Location

  • United States