Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19.

Published

Journal Article

The cDNA and genomic probes for apolipoprotein C2 detect two restriction fragment length polymorphisms on chromosome 19. The combined estimated percentage of heterozygosity, assuming equilibrium, is approximately 75%, ie, apolipoprotein C2 is informative in 75% of matings. We have analyzed over 350 individuals in large multigenerational families for linkage of apolipoprotein C2 to myotonic muscular dystrophy. The maximum lod score was 16.29 with the maximum recombination fraction (theta) of 0.02, with 95% confidence limits for theta of 0.001 to 0.065. Thus, apolipoprotein C2 is useful in carrier detection and prenatal diagnosis with an accuracy of about 98%.

Full Text

Duke Authors

Cited Authors

  • Pericak-Vance, MA; Yamaoka, LH; Assinder, RI; Hung, WY; Bartlett, RJ; Stajich, JM; Gaskell, PC; Ross, DA; Sherman, S; Fey, GH

Published Date

  • November 1986

Published In

Volume / Issue

  • 36 / 11

Start / End Page

  • 1418 - 1423

PubMed ID

  • 3762959

Pubmed Central ID

  • 3762959

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.36.11.1418

Language

  • eng

Conference Location

  • United States