Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
Publication
, Journal Article
St George-Hyslop, P; Haines, J; Rogaev, E; Mortilla, M; Vaula, G; Pericak-Vance, M; Foncin, JF; Montesi, M; Bruni, A; Sorbi, S; Rainero, I ...
Published in: Nat Genet
December 1992
Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score z = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.
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Published In
Nat Genet
DOI
ISSN
1061-4036
Publication Date
December 1992
Volume
2
Issue
4
Start / End Page
330 / 334
Location
United States
Related Subject Headings
- Pedigree
- Molecular Sequence Data
- Middle Aged
- Male
- Lod Score
- Humans
- Genetic Markers
- Female
- Developmental Biology
- DNA
Citation
APA
Chicago
ICMJE
MLA
NLM
St George-Hyslop, P., Haines, J., Rogaev, E., Mortilla, M., Vaula, G., Pericak-Vance, M., … Crapper McLachlan, D. (1992). Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet, 2(4), 330–334. https://doi.org/10.1038/ng1292-330
St George-Hyslop, P., J. Haines, E. Rogaev, M. Mortilla, G. Vaula, M. Pericak-Vance, J. F. Foncin, et al. “Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.” Nat Genet 2, no. 4 (December 1992): 330–34. https://doi.org/10.1038/ng1292-330.
St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G, Pericak-Vance M, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet. 1992 Dec;2(4):330–4.
St George-Hyslop, P., et al. “Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.” Nat Genet, vol. 2, no. 4, Dec. 1992, pp. 330–34. Pubmed, doi:10.1038/ng1292-330.
St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G, Pericak-Vance M, Foncin JF, Montesi M, Bruni A, Sorbi S, Rainero I, Pinessi L, Pollen D, Polinsky R, Nee L, Kennedy J, Macciardi F, Rogaeva E, Liang Y, Alexandrova N, Lukiw W, Schlumpf K, Tanzi R, Tsuda T, Farrer L, Cantu JM, Duara R, Amaducci L, Bergamini L, Gusella J, Roses A, Crapper McLachlan D. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet. 1992 Dec;2(4):330–334.
Published In
Nat Genet
DOI
ISSN
1061-4036
Publication Date
December 1992
Volume
2
Issue
4
Start / End Page
330 / 334
Location
United States
Related Subject Headings
- Pedigree
- Molecular Sequence Data
- Middle Aged
- Male
- Lod Score
- Humans
- Genetic Markers
- Female
- Developmental Biology
- DNA