Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.


Journal Article

Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score z = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.

Full Text

Duke Authors

Cited Authors

  • St George-Hyslop, P; Haines, J; Rogaev, E; Mortilla, M; Vaula, G; Pericak-Vance, M; Foncin, JF; Montesi, M; Bruni, A; Sorbi, S; Rainero, I; Pinessi, L; Pollen, D; Polinsky, R; Nee, L; Kennedy, J; Macciardi, F; Rogaeva, E; Liang, Y; Alexandrova, N; Lukiw, W; Schlumpf, K; Tanzi, R; Tsuda, T; Farrer, L; Cantu, JM; Duara, R; Amaducci, L; Bergamini, L; Gusella, J; Roses, A; Crapper McLachlan, D

Published Date

  • December 1992

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 330 - 334

PubMed ID

  • 1303289

Pubmed Central ID

  • 1303289

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng1292-330


  • eng

Conference Location

  • United States