PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients.


Journal Article

A C-->G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS). We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.

Full Text

Duke Authors

Cited Authors

  • Barcellos, LF; Caillier, S; Dragone, L; Elder, M; Vittinghoff, E; Bucher, P; Lincoln, RR; Pericak-Vance, M; Haines, JL; Weiss, A; Hauser, SL; Oksenberg, JR

Published Date

  • September 2001

Published In

Volume / Issue

  • 29 / 1

Start / End Page

  • 23 - 24

PubMed ID

  • 11528386

Pubmed Central ID

  • 11528386

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng722


  • eng

Conference Location

  • United States