Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.

Journal Article (Journal Article)

Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.

Full Text

Duke Authors

Cited Authors

  • Pericak-Vance, MA; Rimmler, JB; Haines, JL; Garcia, ME; Oksenberg, JR; Barcellos, LF; Lincoln, R; Hauser, SL; Cournu-Rebeix, I; Azoulay-Cayla, A; Lyon-Caen, O; Fontaine, B; Duhamel, E; Coppin, H; Brassat, D; Roth, M-P; Clanet, M; Alizadeh, M; Yaouanq, J; Quelvennec, E; Semana, G; Edan, G; Babron, M-C; Genin, E; Clerget-Darpoux, F

Published Date

  • February 2004

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 45 - 48

PubMed ID

  • 14595552

International Standard Serial Number (ISSN)

  • 1364-6745

Digital Object Identifier (DOI)

  • 10.1007/s10048-003-0163-y


  • eng

Conference Location

  • United States