Linkage of a locus for autosomal dominant familial spastic paraplegia to chromosome 2p markers.

Published

Journal Article

'Pure' autosomal dominant familial spastic paraplegia (SPG) is a neurodegenerative disease which clinically manifests as spasticity of the lower limbs. Dominantly inherited SPG is known to be clinically heterogenous and has been classified into late-onset and early-onset types, based on the age of onset of symptoms. We tested five autosomal dominant SPG families for genetic linkage and established linkage to chromogene 2p markers (Z(theta) = 3.65) with evidence of genetic locus heterogeneity. Three late-onset SPG families and one early-onset SPG family had high posterior probability of linkage (P > 0.94) to chromosome 2p, while the fifth family (a very early-onset family) was not linked to chromosome 2 and showed high probability of linkage to chromosome 14q. These data provide a basis for a classification of SPG according to chromosome location rather than age of onset of symptoms.

Full Text

Duke Authors

Cited Authors

  • Hentati, A; Pericak-Vance, MA; Lennon, F; Wasserman, B; Hentati, F; Juneja, T; Angrist, MH; Hung, WY; Boustany, RM; Bohlega, S

Published Date

  • October 1994

Published In

Volume / Issue

  • 3 / 10

Start / End Page

  • 1867 - 1871

PubMed ID

  • 7849714

Pubmed Central ID

  • 7849714

International Standard Serial Number (ISSN)

  • 0964-6906

Digital Object Identifier (DOI)

  • 10.1093/hmg/3.10.1867

Language

  • eng

Conference Location

  • England