Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17.

Journal Article (Journal Article)

The mutant gene causing von Recklinghausen neurofibromatosis (NF1) was recently shown to map to chromosome 17. We have used additional markers for chromosome 17 to narrow further the location of the gene defect. A preliminary multipoint linkage analysis suggests that the NF1 gene is located on the long arm of chroomsome 17, flanked by D17Z1 and NGFR. Linkage analysis with the human oncogene homolog erbA1, which maps to this region, suggests that this cancer-related gene is not the primary cause of NF1.

Full Text

Duke Authors

Cited Authors

  • Seizinger, BR; Rouleau, GA; Lane, AH; Farmer, G; Ozelius, LJ; Haines, JL; Parry, DM; Korf, BR; Pericak-Vance, MA; Faryniarz, AG

Published Date

  • December 1987

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 346 - 348

PubMed ID

  • 2896628

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(87)90035-8


  • eng

Conference Location

  • United States