Chromosome 17q22-q24 and multiple sclerosis genetic susceptibility. American-French Multiple Sclerosis Genetic Group.

Journal Article (Journal Article)

Recently, genome-wide searches for multiple sclerosis (MS) susceptibility genes have suggested that the chromosome 17q22-q24 region might contain susceptibility genes in two sets of families of different ethnic backgrounds (Finnish and British). Therefore, we decided to test this region in two sets of families of different ethnic backgrounds (American and French), but collected according to the same diagnostic criteria. All lod-score values were non-significant. Moreover, we could exclude that the 17q22-24 region might contain a gene increasing the sibling recurrence risk of MS over 1.4, rendering the existence of such a gene very unlikely, at least in the group of tested families.

Full Text

Duke Authors

Cited Authors

  • Fontaine, B; Cournu, I; Arnaud, I; Babron, MC; Eichenbaum-Voline, S; Oksenberg, JR; Pericak-Vance, MA; Haines, JL; Semama, G; Liblau, R; Lyon-Caen, O; Clerget-Darpoux, F; Clanet, M; Hauser, SL

Published Date

  • November 1999

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 149 - 150

PubMed ID

  • 11196661

International Standard Serial Number (ISSN)

  • 1466-4879

Digital Object Identifier (DOI)

  • 10.1038/sj.gene.6363646


  • eng

Conference Location

  • England