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Linkage analysis in familial amyotrophic lateral sclerosis.

Publication ,  Journal Article
Siddique, T; Pericak-Vance, MA; Brooks, BR; Roos, RP; Hung, WY; Antel, JP; Munsat, TL; Phillips, K; Warner, K; Speer, M
Published in: Neurology
July 1989

Familial amyotrophic lateral sclerosis (FALS) constitutes 5 to 10% of cases of ALS and, in most families, its inheritance is consistent with an autosomal dominant trait with age-dependent penetrance. The biochemical abnormality underlying the disorder is unknown. We analyzed DNA from 131 members of 6 multigenerational ALS families, which included 13 affected members, for genetic linkage to 39 expressed and DNA markers, using the techniques of 2-point linkage analysis, multilocus linkage analysis, and exclusion mapping. We identified FALS families with structures suitable for linkage, by computer simulation techniques. A DNA bank established to provide optimum use of available FALS families provided DNA from immortalized lymphoblast cell lines and frozen postmortem tissue. We could not link FALS to any of the markers studied, but excluded chromosome regions unlikely to be a locus of the FALS gene. With the help of this exclusion data, we will concentrate on regions of the human genome that remain unexcluded.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

July 1989

Volume

39

Issue

7

Start / End Page

919 / 925

Location

United States

Related Subject Headings

  • Pedigree
  • Neurology & Neurosurgery
  • Humans
  • Genetic Markers
  • Genetic Linkage
  • DNA
  • Computer Simulation
  • Chromosome Mapping
  • Amyotrophic Lateral Sclerosis
  • 3209 Neurosciences
 

Citation

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Siddique, T., Pericak-Vance, M. A., Brooks, B. R., Roos, R. P., Hung, W. Y., Antel, J. P., … Speer, M. (1989). Linkage analysis in familial amyotrophic lateral sclerosis. Neurology, 39(7), 919–925. https://doi.org/10.1212/wnl.39.7.919
Siddique, T., M. A. Pericak-Vance, B. R. Brooks, R. P. Roos, W. Y. Hung, J. P. Antel, T. L. Munsat, K. Phillips, K. Warner, and M. Speer. “Linkage analysis in familial amyotrophic lateral sclerosis.Neurology 39, no. 7 (July 1989): 919–25. https://doi.org/10.1212/wnl.39.7.919.
Siddique T, Pericak-Vance MA, Brooks BR, Roos RP, Hung WY, Antel JP, et al. Linkage analysis in familial amyotrophic lateral sclerosis. Neurology. 1989 Jul;39(7):919–25.
Siddique, T., et al. “Linkage analysis in familial amyotrophic lateral sclerosis.Neurology, vol. 39, no. 7, July 1989, pp. 919–25. Pubmed, doi:10.1212/wnl.39.7.919.
Siddique T, Pericak-Vance MA, Brooks BR, Roos RP, Hung WY, Antel JP, Munsat TL, Phillips K, Warner K, Speer M. Linkage analysis in familial amyotrophic lateral sclerosis. Neurology. 1989 Jul;39(7):919–925.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

July 1989

Volume

39

Issue

7

Start / End Page

919 / 925

Location

United States

Related Subject Headings

  • Pedigree
  • Neurology & Neurosurgery
  • Humans
  • Genetic Markers
  • Genetic Linkage
  • DNA
  • Computer Simulation
  • Chromosome Mapping
  • Amyotrophic Lateral Sclerosis
  • 3209 Neurosciences