Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26.
Journal Article (Journal Article)
A genetic map of highly polymorphic microsatellite markers spanning the von Hippel-Lindau region (VHL) of 3p25 was constructed using the CEPH reference pedigrees. A greater than 1000:1 odds map of pter-D3S1038-RAF1-D3S651-D3S656-D3S110- D3S1255-cen was found. Genotyping of six multigenerational VHL families showed the region surrounding the D3S1038 marker to be the most likely location for the VHL gene with a peak location score of 10.04 with VHL completely linked to D3S1038. These data provide an initial high resolution genetic map of this region; D3S1038 appears to be a highly polymorphic marker that should prove useful in the future for presymptomatic diagnosis.
Full Text
Duke Authors
Cited Authors
- Pericak-Vance, MA; Nunes, KJ; Whisenant, E; Loeb, DB; Small, KW; Stajich, JM; Rimmler, JB; Yamaoka, LH; Smith, DI; Drabkin, HA
Published Date
- June 1, 1993
Published In
Volume / Issue
- 30 / 6
Start / End Page
- 487 - 491
PubMed ID
- 8100855
Pubmed Central ID
- 8100855
International Standard Serial Number (ISSN)
- 0022-2593
Digital Object Identifier (DOI)
- 10.1136/jmg.30.6.487
Language
- eng
Conference Location
- England