Flanking markers define the X-linked hypophosphatemic rickets gene locus.


Journal Article

X-linked hypophosphatemic rickets (HYP) is an X-linked dominant disorder characterized by decreased renal tubular phosphate reabsorption and consequent hypophosphatemia. The defect in tubular phosphate reabsorption is probably secondary to an unidentified humoral factor. Identification of the humoral factor and a full understanding of the pathophysiology of the disease await the identification of the HYP gene. Previously we demonstrated that DXS257 and DXS41 are flanking markers for the HYP gene. Two markers, DXS365 and DXS274, are tightly linked to the HYP gene, but investigators have been unable to determine whether they are centromeric or telomeric to the disease gene. Since tightly linked flanking markers are necessary prerequisites to obtain the gene by positional cloning techniques, we sought to determine the relative positions of these markers to the HYP gene by expanding our data base for linkage studies. We also investigated a new polymorphic probe for linkage to HYP to construct a more detailed genetic map around the HYP locus. Our data indicate that the markers DXS365, DXS274, and DXS92 are tightly linked to the HYP locus and suggest a locus order of Xtel-(DXS444/DXS315)-DXS43-(DXS257/DXS3 65)-HYP-(DXS274/DXS41/DXS92)-DXS-451- DXS319-Xeen. These results will facilitate attempts further to localize and clone the HYP gene.

Full Text

Duke Authors

Cited Authors

  • Econs, MJ; Fain, PR; Norman, M; Speer, MC; Pericak-Vance, MA; Becker, PA; Barker, DF; Taylor, A; Drezner, MK

Published Date

  • September 1993

Published In

Volume / Issue

  • 8 / 9

Start / End Page

  • 1149 - 1152

PubMed ID

  • 8237485

Pubmed Central ID

  • 8237485

International Standard Serial Number (ISSN)

  • 0884-0431

Digital Object Identifier (DOI)

  • 10.1002/jbmr.5650080916


  • eng

Conference Location

  • United States