Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers.

Journal Article (Journal Article)

Autosomal recessive familial amyotrophic lateral sclerosis (RFALS) is a rare form of ALS that usually presents at an early age with slow progression of symptoms. RFALS is clinically and genetically heterogeneous and the locus of RFALS type 3 was mapped to 2q33 (ALS2) in a single family. We now report linkage of a more-common form of RFALS to chromosome 15q15-q22 markers (ALS5) and show further genetic locus heterogeneity in RFALS. ALS5 is the locus for most families with RFALS and appears to be present in both North African and European populations.

Full Text

Duke Authors

Cited Authors

  • Hentati, A; Ouahchi, K; Pericak-Vance, MA; Nijhawan, D; Ahmad, A; Yang, Y; Rimmler, J; Hung, W; Schlotter, B; Ahmed, A; Ben Hamida, M; Hentati, F; Siddique, T

Published Date

  • December 1998

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 55 - 60

PubMed ID

  • 9933301

International Standard Serial Number (ISSN)

  • 1364-6745

Digital Object Identifier (DOI)

  • 10.1007/s100480050052


  • eng

Conference Location

  • United States