Linkage and association analysis of chromosome 19q13 in multiple sclerosis.


Journal Article

Multiple sclerosis (MS) is an autoimmune neurological disorder with a complex etiology. Sibling risk, twin, and adoption studies have demonstrated that genes play a vital role in susceptibility to MS. Numerous association and linkage studies have implicated the major histocompatibility complex (MHC) as one component of the genetic etiology, but additional loci remain to be identified. Genomic screens have suggested over 50 regions that might harbor these genes, but there has been little agreement between studies. The one region suggested by all four screens resides within chromosome 19q13. Allelic associations with several markers in this region have also been described. This region has now been examined in detail in an expanded dataset of MS families from the United States. Genetic linkage and association were tested with multiple markers in this region using both parametric and non-parametric analyses. Additional support for an MS susceptibility locus was observed, primarily in families with the MS-associated HLA-DR2 allele. While consistent, this effect appears to be modest with a maximum lambda(s) = 1.47, probably representing no more than 10% of the overall genetic effect in MS.

Full Text

Duke Authors

Cited Authors

  • Pericak-Vance, MA; Rimmler, JB; Martin, ER; Haines, JL; Garcia, ME; Oksenberg, JR; Barcellos, LF; Lincoln, R; Goodkin, DE; Hauser, SL

Published Date

  • October 1, 2001

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • 195 - 201

PubMed ID

  • 11714099

Pubmed Central ID

  • 11714099

International Standard Serial Number (ISSN)

  • 1364-6745

Digital Object Identifier (DOI)

  • 10.1007/s100480100119


  • eng

Conference Location

  • United States