Whole-blood serotonin and cognitive functioning in autistic individuals and their first-degree relatives.


Journal Article

The relationship between cognitive-intellectual abilities and whole-blood serotonin (5-hydroxytryptamine; 5-HT) in 18 autistic probands and their first-degree relatives (n = 21 parents, n = 13 siblings) was investigated. Whole-blood 5-HT was significantly negatively associated with verbal-expressive/symbolic abilities for the entire sample. The proportion of variance in cognitive-intellectual performances attributable to whole-blood 5-HT was substantial in the context of variance attributable to familial classification. The relationship between verbal-expressive abilities and whole-blood 5-HT, adjusted for race and familial classification, was noteworthy. Simple correlations between 5-HT and cognitive-intellectual performances were conducted. However, bias related to covariance attributable to race seriously limits such findings. The issue of bias and its relevance to previous research is discussed further.

Full Text

Cited Authors

  • Cuccaro, ML; Wright, HH; Abramson, RK; Marsteller, FA; Valentine, J

Published Date

  • January 1, 1993

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 94 - 101

PubMed ID

  • 8428142

Pubmed Central ID

  • 8428142

Electronic International Standard Serial Number (EISSN)

  • 1545-7222

International Standard Serial Number (ISSN)

  • 0895-0172

Digital Object Identifier (DOI)

  • 10.1176/jnp.5.1.94


  • eng