Scholars@Duke publication: The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.

The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.

Publication , Journal Article

Loftus, BJ; Fung, E; Roncaglia, P; Rowley, D; Amedeo, P; Bruno, D; Vamathevan, J; Miranda, M; Anderson, IJ; Fraser, JA; Allen, JE; Bosdet, IE ...

Published in: Science

February 25, 2005

Published version (DOI) Link to item

Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.

Duke Scholars

Author Thomas Greenfield Mitchell Molecular Genetics and Microbiology

Author Jennifer Lodge Molecular Genetics and Microbiology

Author Joseph Heitman Molecular Genetics and Microbiology

Altmetric Attention Stats

Dimensions Citation Stats

Published In

Science

DOI

10.1126/science.1103773

EISSN

1095-9203

Publication Date

February 25, 2005

Volume

307

Issue

5713

Start / End Page

1321 / 1324

Location

United States

Related Subject Headings

Virulence Factors
Virulence
Transcription, Genetic
Sequence Analysis, DNA
RNA, Antisense
Polysaccharides
Polymorphism, Single Nucleotide
Polymorphism, Genetic
Phenotype
Molecular Sequence Data

Citation

APA

Chicago

ICMJE

MLA

NLM

Loftus, B. J., Fung, E., Roncaglia, P., Rowley, D., Amedeo, P., Bruno, D., … Hyman, R. W. (2005). The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science, 307(5713), 1321–1324. https://doi.org/10.1126/science.1103773

Loftus, Brendan J., Eula Fung, Paola Roncaglia, Don Rowley, Paolo Amedeo, Dan Bruno, Jessica Vamathevan, et al. “The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.” Science 307, no. 5713 (February 25, 2005): 1321–24. https://doi.org/10.1126/science.1103773.

Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, et al. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science. 2005 Feb 25;307(5713):1321–4.

Loftus, Brendan J., et al. “The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.” Science, vol. 307, no. 5713, Feb. 2005, pp. 1321–24. Pubmed, doi:10.1126/science.1103773.

Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson IJ, Fraser JA, Allen JE, Bosdet IE, Brent MR, Chiu R, Doering TL, Donlin MJ, D’Souza CA, Fox DS, Grinberg V, Fu J, Fukushima M, Haas BJ, Huang JC, Janbon G, Jones SJM, Koo HL, Krzywinski MI, Kwon-Chung JK, Lengeler KB, Maiti R, Marra MA, Marra RE, Mathewson CA, Mitchell TG, Pertea M, Riggs FR, Salzberg SL, Schein JE, Shvartsbeyn A, Shin H, Shumway M, Specht CA, Suh BB, Tenney A, Utterback TR, Wickes BL, Wortman JR, Wye NH, Kronstad JW, Lodge JK, Heitman J, Davis RW, Fraser CM, Hyman RW. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science. 2005 Feb 25;307(5713):1321–1324.

Published In

Science

DOI

10.1126/science.1103773

EISSN

1095-9203

Publication Date

February 25, 2005

Volume

307

Issue

5713

Start / End Page

1321 / 1324

Location

United States

Related Subject Headings

Virulence Factors
Virulence
Transcription, Genetic
Sequence Analysis, DNA
RNA, Antisense
Polysaccharides
Polymorphism, Single Nucleotide
Polymorphism, Genetic
Phenotype
Molecular Sequence Data