Analysis of cytokine dynamics in corneal allograft rejection.
Publication
, Journal Article
Chan, CC; Stark, J; George, AJ
Published in: Proc Biol Sci
November 7, 1999
Motivated by the discovery of oscillations in tumour necrosis factor-alpha (TNF-alpha) concentration in the aqueous humour of rabbits undergoing corneal allograft rejection, a simple mathematical model is developed for the regulation of TNF-alpha, which incorporates both negative feedback and amplification pathways. Mathematical analysis reveals a surprisingly rich behavioural repertoire for this simple cytokine pathway, including excitability, threshold behaviour, hysteresis, oscillations and bistability. This suggests new possibilities for experimental demonstration, and reveals the potential contributions of nonlinear dynamics to understanding cytokine regulation.
Duke Scholars
Published In
Proc Biol Sci
DOI
ISSN
0962-8452
Publication Date
November 7, 1999
Volume
266
Issue
1434
Start / End Page
2217 / 2223
Location
England
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Transplantation, Homologous
- Time Factors
- Rabbits
- Models, Theoretical
- Models, Immunological
- Graft Rejection
- Corneal Transplantation
- Animals
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Chan, C. C., Stark, J., & George, A. J. (1999). Analysis of cytokine dynamics in corneal allograft rejection. Proc Biol Sci, 266(1434), 2217–2223. https://doi.org/10.1098/rspb.1999.0911
Chan, C. C., J. Stark, and A. J. George. “Analysis of cytokine dynamics in corneal allograft rejection.” Proc Biol Sci 266, no. 1434 (November 7, 1999): 2217–23. https://doi.org/10.1098/rspb.1999.0911.
Chan CC, Stark J, George AJ. Analysis of cytokine dynamics in corneal allograft rejection. Proc Biol Sci. 1999 Nov 7;266(1434):2217–23.
Chan, C. C., et al. “Analysis of cytokine dynamics in corneal allograft rejection.” Proc Biol Sci, vol. 266, no. 1434, Nov. 1999, pp. 2217–23. Pubmed, doi:10.1098/rspb.1999.0911.
Chan CC, Stark J, George AJ. Analysis of cytokine dynamics in corneal allograft rejection. Proc Biol Sci. 1999 Nov 7;266(1434):2217–2223.
Published In
Proc Biol Sci
DOI
ISSN
0962-8452
Publication Date
November 7, 1999
Volume
266
Issue
1434
Start / End Page
2217 / 2223
Location
England
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Transplantation, Homologous
- Time Factors
- Rabbits
- Models, Theoretical
- Models, Immunological
- Graft Rejection
- Corneal Transplantation
- Animals
- 11 Medical and Health Sciences