Analysis of cytokine dynamics in corneal allograft rejection.

Journal Article (Journal Article)

Motivated by the discovery of oscillations in tumour necrosis factor-alpha (TNF-alpha) concentration in the aqueous humour of rabbits undergoing corneal allograft rejection, a simple mathematical model is developed for the regulation of TNF-alpha, which incorporates both negative feedback and amplification pathways. Mathematical analysis reveals a surprisingly rich behavioural repertoire for this simple cytokine pathway, including excitability, threshold behaviour, hysteresis, oscillations and bistability. This suggests new possibilities for experimental demonstration, and reveals the potential contributions of nonlinear dynamics to understanding cytokine regulation.

Full Text

Duke Authors

Cited Authors

  • Chan, CC; Stark, J; George, AJ

Published Date

  • November 7, 1999

Published In

Volume / Issue

  • 266 / 1434

Start / End Page

  • 2217 - 2223

PubMed ID

  • 10649636

Pubmed Central ID

  • PMC1690347

International Standard Serial Number (ISSN)

  • 0962-8452

Digital Object Identifier (DOI)

  • 10.1098/rspb.1999.0911


  • eng

Conference Location

  • England