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Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.

Publication ,  Journal Article
Göker, E; Lin, JT; Trippett, T; Elisseyeff, Y; Tong, WP; Niedzwiecki, D; Tan, C; Steinherz, P; Schweitzer, BI; Bertino, JR
Published in: Leukemia
July 1993

We compared blast cells from adult and pediatric patients with untreated acute lymphoblastic leukemia (ALL) (as separated groups of T-lineage cell and B-lineage cell ALL) to determine if methotrexate (MTX) polyglutamate formation in adult patients might be a contributing cause to the known difference in clinical outcome, since MTX is a key drug in chemotherapy regimens. Adult B-lineage cell ALL blasts and blasts from the patients with T-lineage cell ALL accumulated lower amounts of total MTX and polyglutamates, especially long-chain MTX polyglutamates (glu3-6) than pediatric B-lineage cell ALL blasts. In view of the importance of polyglutamylation of MTX as a determinant of cytotoxicity of this drug, decreased formation of MTX polyglutamates is likely a contributing cause to the lower cure rate in adult ALL and T-lineage cell ALL as compared to childhood B-lineage cell ALL.

Duke Scholars

Published In

Leukemia

ISSN

0887-6924

Publication Date

July 1993

Volume

7

Issue

7

Start / End Page

1000 / 1004

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Polyglutamic Acid
  • Methotrexate
  • In Vitro Techniques
  • Immunology
  • Humans
  • Drug Resistance
  • Child
  • Age Factors
 

Citation

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Göker, E., Lin, J. T., Trippett, T., Elisseyeff, Y., Tong, W. P., Niedzwiecki, D., … Bertino, J. R. (1993). Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease. Leukemia, 7(7), 1000–1004.
Göker, E., J. T. Lin, T. Trippett, Y. Elisseyeff, W. P. Tong, D. Niedzwiecki, C. Tan, P. Steinherz, B. I. Schweitzer, and J. R. Bertino. “Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.Leukemia 7, no. 7 (July 1993): 1000–1004.
Göker E, Lin JT, Trippett T, Elisseyeff Y, Tong WP, Niedzwiecki D, et al. Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease. Leukemia. 1993 Jul;7(7):1000–4.
Göker E, Lin JT, Trippett T, Elisseyeff Y, Tong WP, Niedzwiecki D, Tan C, Steinherz P, Schweitzer BI, Bertino JR. Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease. Leukemia. 1993 Jul;7(7):1000–1004.

Published In

Leukemia

ISSN

0887-6924

Publication Date

July 1993

Volume

7

Issue

7

Start / End Page

1000 / 1004

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Polyglutamic Acid
  • Methotrexate
  • In Vitro Techniques
  • Immunology
  • Humans
  • Drug Resistance
  • Child
  • Age Factors