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Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001.

Publication ,  Journal Article
Redston, M; Compton, CC; Miedema, BW; Niedzwiecki, D; Dowell, JM; Jewell, SD; Fleshman, JM; Bem, J; Mayer, RJ; Bertagnolli, MM ...
Published in: J Clin Oncol
February 20, 2006

PURPOSE: To determine whether sentinel lymph node (LN) sampling (SLNS) could reduce the number of nodes required to characterize micrometastatic disease (MMD) in patients with potentially curable colon cancer. PATIENTS AND METHODS: Cancer and Leukemia Group B 80001 was a study to determine whether SLNS could identify a subset of LNs that predicted the status of the nodal basin for resectable colon cancer and, therefore, could be extensively evaluated for the presence of micrometastases. Patients enrolled onto this study underwent SLNS after injection of 1% isosulfan blue, and both sentinel nodes (SNs) and non-SNs obtained during primary tumor resection were sectioned at multiple levels and stained using anti-carcinoembryonic antigen and anticytokeratin antibodies. RESULTS: Using standard histopathology, SNs failed to predict the presence of nodal disease in 13 (54%) of 24 node-positive patients. Immunostains were performed for patients whose LNs were negative by standard histopathology. Depending on the immunohistochemical criteria used to assign LN positivity, SN examination resulted in either an unacceptably high false-positive rate (20%) or a low sensitivity for detection of MMD (40%). CONCLUSION: By examining both SNs and non-SNs, this multi-institutional study showed that SNs did not accurately predict the presence of either conventionally defined nodal metastases or MMD. As a result, SLNS is not a useful technique for the study of MMD in patients with colon cancer.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

February 20, 2006

Volume

24

Issue

6

Start / End Page

878 / 883

Location

United States

Related Subject Headings

  • Sentinel Lymph Node Biopsy
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Lymphatic Metastasis
  • Lymph Nodes
  • Keratins
  • Immunohistochemistry
  • Humans
  • Colonic Neoplasms
 

Citation

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Redston, M., Compton, C. C., Miedema, B. W., Niedzwiecki, D., Dowell, J. M., Jewell, S. D., … Leukemia Group B Trial 80001, . (2006). Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001. J Clin Oncol, 24(6), 878–883. https://doi.org/10.1200/JCO.2005.03.6038
Redston, Mark, Carolyn C. Compton, Brent W. Miedema, Donna Niedzwiecki, Jeannette M. Dowell, Scott D. Jewell, James M. Fleshman, et al. “Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001.J Clin Oncol 24, no. 6 (February 20, 2006): 878–83. https://doi.org/10.1200/JCO.2005.03.6038.
Redston M, Compton CC, Miedema BW, Niedzwiecki D, Dowell JM, Jewell SD, et al. Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001. J Clin Oncol. 2006 Feb 20;24(6):878–83.
Redston, Mark, et al. “Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001.J Clin Oncol, vol. 24, no. 6, Feb. 2006, pp. 878–83. Pubmed, doi:10.1200/JCO.2005.03.6038.
Redston M, Compton CC, Miedema BW, Niedzwiecki D, Dowell JM, Jewell SD, Fleshman JM, Bem J, Mayer RJ, Bertagnolli MM, Leukemia Group B Trial 80001. Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001. J Clin Oncol. 2006 Feb 20;24(6):878–883.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

February 20, 2006

Volume

24

Issue

6

Start / End Page

878 / 883

Location

United States

Related Subject Headings

  • Sentinel Lymph Node Biopsy
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Lymphatic Metastasis
  • Lymph Nodes
  • Keratins
  • Immunohistochemistry
  • Humans
  • Colonic Neoplasms