Intrahepatic mitomycin C as a salvage treatment for patients with hepatic metastases from colorectal carcinoma.

Journal Article (Journal Article)

Sixty-four evaluable patients with hepatic metastases from colorectal carcinoma, who did not have evidence of extrahepatic disease, were treated with intrahepatic (IH) mitomycin C (M) after disease progression or intolerance to treatment with IH fluorodeoxyuridine (FUDR). Eleven patients (17%) had a partial response (PR) to IH M and ten (16%) patients had stable disease. Patients who responded to IH FUDR were more likely to respond to IH M when compared with those who progressed on IH FUDR (47% versus 13%, respectively; P = 0.013). Those who were switched to IH M because of hepatotoxicity on IH FUDR also were more likely to respond to IH M than those who were switched because of progression on IH FUDR (75% versus 27%, respectively; P = 0.022). Baseline laboratory values, the percent of tumorous liver involvement, prior history of systemic chemotherapy, and the interval from diagnosis to initiation of IH M did not help predict response. Toxicity was mild and well tolerated. The overall median survival time of the 64 evaluable patients was 9.0 months from the start of IH M therapy. We conclude that IH M has some salvage benefit in patients with hepatic metastases.

Full Text

Duke Authors

Cited Authors

  • Schneider, A; Kemeny, N; Chapman, D; Niedzwiecki, D; Oderman, P

Published Date

  • December 1, 1989

Published In

Volume / Issue

  • 64 / 11

Start / End Page

  • 2203 - 2206

PubMed ID

  • 2529960

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19891201)64:11<2203::aid-cncr2820641103>;2-o


  • eng

Conference Location

  • United States