Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer.


Journal Article

Nausea and immune function were assessed in 20 cancer patients in the hospital prior to chemotherapy and compared with assessments conducted at home. Proliferative responses to T-cell mitogens were lower for cells isolated from hospital blood samples than for home samples obtained several days earlier. Patients also experienced increased nausea in the hospital. Hierarchical multiple regression analyses indicated that decreased immune function in the hospital was not related to increased anxiety. The observed anticipatory immune suppression is consistent with the hypothesis that chemotherapy patients may develop conditioned immune suppression as well as conditioned nausea after repeated pairings of hospital stimuli with the emetic and immunosuppressive effects of chemotherapy.

Full Text

Duke Authors

Cited Authors

  • Bovbjerg, DH; Redd, WH; Maier, LA; Holland, JC; Lesko, LM; Niedzwiecki, D; Rubin, SC; Hakes, TB

Published Date

  • April 1990

Published In

Volume / Issue

  • 58 / 2

Start / End Page

  • 153 - 157

PubMed ID

  • 2335631

Pubmed Central ID

  • 2335631

International Standard Serial Number (ISSN)

  • 0022-006X

Digital Object Identifier (DOI)

  • 10.1037//0022-006x.58.2.153


  • eng

Conference Location

  • United States