Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes.

Journal Article (Journal Article)

E2A has been shown to be an important transcription factor downstream of the T-cell receptor (TCR) signal during T-cell development. The TCR signal is known to elicit different cellular responses at different stages of T-cell development. Whether E2A is still required for normal TCR signalling in mature T cells is unknown. Here we examined T-cell function after disruption of the E2A gene exclusively in the T-cell lineage. The conditional E2A-deficient mice show enhanced humoral immunity to a T-dependent antigen. We further show that E2A is involved in regulating TCR-induced T-cell proliferation events. However, E2A seems to play opposite roles in naïve and effector T cells. In the absence of E2A, TCR-induced proliferation is increased in naïve T cells and decreased in effector T cells. At older ages, these mice frequently develop antinuclear antibodies and proteinuria. Our studies suggest that E2A regulates T-cell function and the loss of E2A may promote age-dependent autoimmune diseases.

Full Text

Duke Authors

Cited Authors

  • Pan, L; Bradney, C; Zheng, B; Zhuang, Y

Published Date

  • February 2004

Published In

Volume / Issue

  • 111 / 2

Start / End Page

  • 147 - 154

PubMed ID

  • 15027899

Pubmed Central ID

  • PMC1782409

International Standard Serial Number (ISSN)

  • 0019-2805

Digital Object Identifier (DOI)

  • 10.1111/j.0019-2805.2003.01802.x


  • eng

Conference Location

  • England