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A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome.

Publication ,  Journal Article
Li, H; Dai, M; Zhuang, Y
Published in: Immunity
October 2004

Sjogren's syndrome is an autoimmune disease with clinical hallmarks of keratoconjunctivitis sicca (dry eyes) and xerostomia (dry mouth). The genetic basis of this autoimmune disease is poorly understood. Id3 is an immediate early-response gene in growth regulation and is involved in TCR-mediated T cell selection during T cell development. Here, we show that Id3-deficient mice develop many disease symptoms found in primary Sjogren's syndrome patients including dry eyes and mouth, lymphocyte infiltration in lachrymal and salivary glands, and development of anti-Ro and anti-La antibodies. Adoptive transfer experiment indicated a T cell intrinsic role for Id3 in the development of Sjogren's symptoms. Furthermore, genetic ablation of T cells or neonatal 3 day thymectomy in Id3-deficient mice showed a rescue of disease symptoms, suggesting a thymic origin of autoimmune T cells. Thus, this study establishes a critical connection between Id3-mediated T cell development and autoimmune diseases.

Duke Scholars

Published In

Immunity

DOI

ISSN

1074-7613

Publication Date

October 2004

Volume

21

Issue

4

Start / End Page

551 / 560

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Sjogren's Syndrome
  • Salivary Gland Diseases
  • Neoplasm Proteins
  • Mice, Knockout
  • Mice
  • Male
  • Immunology
  • Fluorescent Antibody Technique
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Li, H., Dai, M., & Zhuang, Y. (2004). A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity, 21(4), 551–560. https://doi.org/10.1016/j.immuni.2004.08.013
Li, Hongmei, Meifang Dai, and Yuan Zhuang. “A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome.Immunity 21, no. 4 (October 2004): 551–60. https://doi.org/10.1016/j.immuni.2004.08.013.
Li H, Dai M, Zhuang Y. A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity. 2004 Oct;21(4):551–60.
Li, Hongmei, et al. “A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome.Immunity, vol. 21, no. 4, Oct. 2004, pp. 551–60. Pubmed, doi:10.1016/j.immuni.2004.08.013.
Li H, Dai M, Zhuang Y. A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity. 2004 Oct;21(4):551–560.
Journal cover image

Published In

Immunity

DOI

ISSN

1074-7613

Publication Date

October 2004

Volume

21

Issue

4

Start / End Page

551 / 560

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Sjogren's Syndrome
  • Salivary Gland Diseases
  • Neoplasm Proteins
  • Mice, Knockout
  • Mice
  • Male
  • Immunology
  • Fluorescent Antibody Technique
  • Female