New insights into E-protein function in lymphocyte development.

Journal Article (Journal Article;Review)

Lymphocyte development has long served as an experimental paradigm, revealing fundamental mechanisms of gene regulation and cellular differentiation in mammals. The study of E-protein-mediated transcriptional regulation in lymphocyte development provides a means to address these mechanistic issues. Both genetic and biochemical studies have defined many important regulatory events during lymphocyte development that are mediated by E-proteins. The E2A gene, one of the three known E-protein genes in mammals, has a particularly important role in B-lymphocyte development. Major progress has been made in recent years towards understanding the physiological targets of E2A during B-lymphocyte development. Most notably, new insights have been gained regarding the role of E2A in controlling lineage commitment and V(D)J recombination. This Review focuses primarily on E2A-mediated gene regulation during B-lymphocyte development.

Full Text

Duke Authors

Cited Authors

  • Lazorchak, A; Jones, ME; Zhuang, Y

Published Date

  • June 2005

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 334 - 338

PubMed ID

  • 15922950

International Standard Serial Number (ISSN)

  • 1471-4906

Digital Object Identifier (DOI)

  • 10.1016/j.it.2005.03.011

Language

  • eng

Conference Location

  • England