New insights into E-protein function in lymphocyte development.

Published

Journal Article (Review)

Lymphocyte development has long served as an experimental paradigm, revealing fundamental mechanisms of gene regulation and cellular differentiation in mammals. The study of E-protein-mediated transcriptional regulation in lymphocyte development provides a means to address these mechanistic issues. Both genetic and biochemical studies have defined many important regulatory events during lymphocyte development that are mediated by E-proteins. The E2A gene, one of the three known E-protein genes in mammals, has a particularly important role in B-lymphocyte development. Major progress has been made in recent years towards understanding the physiological targets of E2A during B-lymphocyte development. Most notably, new insights have been gained regarding the role of E2A in controlling lineage commitment and V(D)J recombination. This Review focuses primarily on E2A-mediated gene regulation during B-lymphocyte development.

Full Text

Duke Authors

Cited Authors

  • Lazorchak, A; Jones, ME; Zhuang, Y

Published Date

  • June 2005

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 334 - 338

PubMed ID

  • 15922950

Pubmed Central ID

  • 15922950

International Standard Serial Number (ISSN)

  • 1471-4906

Digital Object Identifier (DOI)

  • 10.1016/j.it.2005.03.011

Language

  • eng

Conference Location

  • England